Altered antibodies and their preparation
USRE43898E1 · kind E1 · reissue
2Cited by
5References
19Claims
0Family size
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Key dates
| Filing date | Sep 16, 1991 |
| Grant date | Jan 1, 2013 |
| Priority date | — |
| Expiry date | Sep 16, 2011 |
Classification
- Technology area (CPC —)General
Abstract
An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.