6-mercapto-cyclodextrin derivatives:reversal agents for drug-induced neuromuscular block

USRE44733E1 · kind E1 · reissue

Assignee

• MERCK SHARP & DOHME B.V. · NL

Inventors

• Mingiang Zhang · Montréal, CA
• Ronald Palin · Banton, GB
• Jonathan Bennett · Rock Hill, US

Key dates

• Filing date: Mar 28, 2012
• Grant date: Jan 28, 2014
• Expiry date: Mar 28, 2032

Classification

• Technology area (CPC —): General

Abstract

Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6)alkylene, optionally substituated with 1-3 OH groups, or (CH2)o-phenylene-(CH2)p—; o and p are independently 0-4; X is COOH, CONHR1, NHCOR2, SO2OH, PO(OH)2, O(CH2—CH2—O)q—H, OH or tetrazol-5-yl; R1 is H or (C1-3)alkyl; R2 is carboxyphenyl; q is 1-3; or pharmaceutically acceptable salts thereof. The 6-mercaptocyclodextrin derivative is highly suitable for use in the reversal of drug-induced neuromuscular block.