Compositions and methods for enhancing contrast in imaging

USRE45195E1 · kind E1 · reissue

Assignees

• Marval Pharma, Inc. · US
• CASE WESTERN RESERVE UNIVERSITY · US
• Cleveland State University · US

Inventors

• Ananth Annapragada · Manvel, US
• Ravi V. Bellamkonda · Atlanta, US
• Eric Hoffman · Iowa City, US
• Chandra Vijayalakshmi · Manvel, US
• Chen-Yu Kao · Hsinchu, TW

Key dates

• Filing date: Feb 15, 2013
• Grant date: Oct 14, 2014
• Expiry date: Feb 15, 2033

Classification

• Technology area (CPC —): General

Abstract

Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.