N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

USRE45314E1 · kind E1 · reissue

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• Cardioxyl Pharmaceuticals, Inc. · US

Inventors

• John P. Toscano · Glen Arm, US
• Frederick Arthur Brookfield · Woodstock, GB
• Andrew D. Cohen · Mamaroneck, US
• Stephen Martin Courtney · Woodstock, GB
• Lisa Marie Frost · Abingdon, GB
• Vincent Jacob Kalish · Annapolis, US

Key dates

• Filing date: Oct 3, 2013
• Grant date: Dec 30, 2014
• Expiry date: Oct 3, 2033

Classification

• Technology area (CPC —): General

Abstract

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.