Optimized FC variants

USRE45992E1 · kind E1 · reissue

Assignee

• Laboratoire Francais du Fractionnement et des Biotechnologies · FR

Inventors

• Christian Behrens · Palaiseau, FR
• Sylvie Jorieux · Lomme, FR
• Abdelhakim Kharrat · Ramonville-Saint-Agne, FR
• Khalil Bouayadi · Toulouse, FR
• Philippe Mondon · Donneville, FR
• Celine Monnet-Mars · Lambersart, FR

Key dates

• Filing date: Jul 23, 2014
• Grant date: May 3, 2016
• Expiry date: Jul 23, 2034

Classification

• Technology area (CPC —): General

Abstract

A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification in the Fc region.