Variants of C-type natriuretic peptide

USRE46707E1 · kind E1 · reissue

Assignee

• BIOMARIN PHARMACEUTICAL INC. · US

Inventors

• Daniel J. Wendt · Novato, US
• Shinong Long · Milpitas, US
• Sianna Castillo · Novato, US
• Christopher P. Price · Aachen, DE
• Mika Aoyagi-Scharber · Novato, US
• Michel Claude Vellard · San Rafael, US
• Augustus O. Okhamafe · Concord, US

Key dates

• Filing date: Jan 23, 2015
• Grant date: Feb 13, 2018
• Expiry date: Jan 23, 2035

Classification

• Technology area (CPC —): General

Abstract

The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).