Altered antibodies and their preparation
USRE46877E1 · kind E1 · reissue
1Cited by
14References
7Claims
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Key dates
| Filing date | Nov 21, 2012 |
| Grant date | May 29, 2018 |
| Priority date | — |
| Expiry date | Nov 21, 2032 |
Classification
- Technology area (CPC —)General
Abstract
An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from a second different mammalian species. The or each constant domain of the antibody chain, if present, are also derived from the second mammalian species.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.