Nanopore sequencing using ratiometric impedance

USRE47067E1 · kind E1 · reissue

Assignee

• PACIFIC BIOSCIENCES OF CALIFORNIA, INC. · US

Inventors

• Stephen Turner · Menlo Park, US
• Nathaniel Joseph McCaffrey · Clifton, US
• Jeffrey Wegener · Cupertino, US
• Adrian Fehr · San Francisco, US

Key dates

• Filing date: Jul 28, 2015
• Grant date: Oct 2, 2018
• Expiry date: Jul 28, 2035

Classification

• Technology area (CPC —): General

Abstract

The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. The invention includes devices having sample and reference pores connecting sample, measurement and reference chambers, wherein potential measurements in each chamber is used to provide an accurate determination of current through a sample nanopore, improving nanopore sequencing.