Cephem compounds, their production and use

USRE48097E1 · kind E1 · reissue

Assignee

• NAEJA-RGM PHARMACEUTICALS ULC · CA

Inventors

• Samarendra N. Maiti · Swan Hills, CA
• Dai Nguyen · Edmonton, CA
• Andhe Reddy · Swan Hills, CA
• Judy Yip · Swan Hills, CA
• Chan Ha · Edmonton, CA
• Rong Ling · Edmonton, CA
• Rudong Shan · Swan Hills, CA
• Madhava Reddy Madala · Swan Hills, CA

Key dates

• Filing date: Dec 19, 2018
• Grant date: Jul 14, 2020
• Expiry date: Dec 19, 2038

Classification

• Technology area (CPC —): General

Abstract

Cephem compounds, pharmaceutically acceptable salts thereof, and methods of using same, wherein the compound has a bicyclic nitrogen-containing aromatic heterocyclic ring as the quaternary ammoniomethyl group at the 3-position and one or both of a terminal amidine residue (substituted or unsubstituted) attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain, or a terminal guanidine residue attached to an aryl or a 5- or 6-membered heteroaryl group (substituted or unsubstituted) which is further attached through a spacer to the free N-atom of the quaternary nitrogen-containing bicyclic ring at the 3-side chain.