Hybrid hepatocyte growth factor gene having high expression efficiency of two heterotypes of hepatocyte growth factor
USRE48404E1 · kind E1 · reissue
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Key dates
| Filing date | Jul 5, 2017 |
| Grant date | Jan 26, 2021 |
| Priority date | — |
| Expiry date | Jul 5, 2037 |
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- Technology area (CPC —)General
Abstract
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.
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