Inhibition of a lncRNA for treatment of melanoma

USRE48801E1 · kind E1 · reissue

Assignees

• VIB VZW · BE
• Katholieke Universiteit Leuven, KU LEUVEN R&D · BE
• UNIVERSITEIT GENT · BE

Inventors

• Jean-Christophe Marine · Brussels, BE
• Eleonora Leucci · Linden, BE
• Joke Vandesompele · Zwijnaarde, BE
• Pieter Mestdagh · Brugge, BE

Key dates

• Filing date: Nov 20, 2019
• Grant date: Nov 2, 2021
• Expiry date: Nov 20, 2039

Classification

• Technology area (CPC —): General

Abstract

This disclosure relates to the field of cancer, particularly the field of melanoma. It was found that a particular long non-coding RNA (lncRNA) is specifically up-regulated in melanoma (but not other tumor) cells as compared to melanocytes. Inhibition of this lncRNA in melanoma cells leads to induction of apoptosis and is a novel therapeutic strategy in the treatment of melanoma.