Method for synthesizing optically active carbonyl compounds

USRE49036E1 · kind E1 · reissue

Assignee

• BASF SE

Inventors

• Mathias Schelwies · Ludwigshafen am Rhein, DE
• Rocco Paciello · Bad Dürkheim, DE
• Gunnar Heydrich · Schifferstadt, DE
• Günter Wegner · Charlotte, US
• Gerd-Dieter Tebben · Mannheim, DE
• Martin Haubner · Ludwigshafen am Rhein, DE
• Andreas Keller · Speyer, DE
• Oliver Bey · Niederkirchen, DE
• Stephanie RENZ · Ludwigshafen am Rhein, DE
• Georg Seeber · Lambsheim, DE

Key dates

• Filing date: Jul 25, 2019
• Grant date: Apr 19, 2022
• Expiry date: Jul 25, 2039

Classification

• Technology area (CPC —): General

Abstract

The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I):