Compositions and methods for treating renal disease

USRE49076E1 · kind E1 · reissue

Assignee

• Beth Israel Deaconess Medical Center, Inc. · US

Inventors

• David J. Friedman · San Antonio, US
• Martin R. Pollak · Brookline, US

Key dates

• Filing date: Jul 23, 2019
• Grant date: May 17, 2022
• Expiry date: Jul 23, 2039

Classification

• Technology area (CPC —): General

Abstract

Compositions and methods are disclosed herein for treating or reducing the symptoms of a renal disease, such as focal segmental glomerulosclerosis (FSGS), hypertensive end-stage kidney disease (ESKD), and HIV-associated nephropathy (a distinct form of FSGS, also termed collapsing glomerulopathy). The compositions include the common variant of APOL1 and fragments thereof, as well as antibodies and fragments thereof that bind and neutralize pathogenic APOL1, nucleic acid molecules that encode the common variant of APOL1 and fragments thereof, and other compounds that bind and neutralize pathogenic APOL1. The methods of the invention include administering one or more of the compositions of the invention to a subject having or at risk of developing renal disease.