Pegylated L-asparaginase
USRE49736E1 · kind E1 · reissue
Assignee
Inventor
Key dates
| Filing date | Mar 18, 2020 |
| Grant date | Nov 28, 2023 |
| Priority date | — |
| Expiry date | Mar 18, 2040 |
Classification
- Technology area (CPC —)General
Abstract
Disclosed is a conjugate of a protein having substantial L-asparagine aminohydrolase activity and polyethylene glycol. In particular, the polyethylene glycol has a molecular weight less than or equal to about 5000 Da and the protein is an L-asparaginase from Erwinia. The conjugate of the invention has shown superior properties such as maintenance of a high level of in vitro activity and an unexpected increase in half-life in vivo. Also disclosed are methods of producing the conjugate and use of the conjugate in therapy. In particular, a method is disclosed for use of the conjugate in the treatment of cancer, particularly Acute Lymphoblastic Leukemia (ALL). More specifically, a method is disclosed for use of the conjugate as a second line therapy for patients who have developed hypersensitivity or have had a disease relapse after treatment with other L-asparaginase preparations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.