Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors

USRE50594E1 · kind E1 · reissue

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Andreas Gollner · Wien, AT
• Joachim BROEKER · Miedling, AT
• Nina Kerres · Wien, AT
• Christiane Kofink · Perchtoldsdorf, AT
• Juergen Ramharter · Wien, AT
• Harald WEINSTABL · Wien, AT
• Annika Gille · Ulm, DE
• Stefan Goepper · Bad Herrenalb, DE
• Manuel HENRY · Schemmerhofen, DE
• Guenther Huchler · Biberach an der Riß, DE

Key dates

• Filing date: Jan 4, 2023
• Grant date: Sep 23, 2025
• Expiry date: Jan 4, 2043

Classification

• Technology area (CPC —): General

Abstract

The present invention encompasses intermediates for preparing compounds of formula (I) wherein the groups R1 to R4, R7, A, D, E, F, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p53 interaction, pharmaceutical compositions which contain compounds of this kind, their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases, and synthetic intermediates.