Patent assignee · US · COMPANY

Alnylam Pharmaceuticals, Inc.

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433Patents
413Active
433Granted
59Portfolio score

Filing activity: Mar 6, 2003 → Oct 28, 2024 · 102 expiring within 5 years

Most-cited patents

PatentTitleAreaCited byStatus
US8158601B2 Lipid formulation Emerging Cross-Sectional Technologies 293 Active
US8106022B2 Carbohydrate conjugates as delivery agents for oligonucleotides Emerging Cross-Sectional Technologies 229 Active
US7718629B2 Compositions and methods for inhibiting expression of Eg5 gene Chemistry; Metallurgy 211 Active
US7320965B2 Compositions and methods for inhibiting expression of Huntingtin gene Chemistry; Metallurgy 167 Active
US8828956B2 Carbohydrate conjugates as delivery agents for oligonucleotides Emerging Cross-Sectional Technologies 160 Active
US7605251B2 Compositions and methods for inhibiting expression of the PCSK9 gene Chemistry; Metallurgy 149 Active
US7582745B2 Compositions and methods for inhibiting expression of Nav1.8 gene Chemistry; Metallurgy 146 Active
US8450467B2 Carbohydrate conjugates as delivery agents for oligonucleotides Emerging Cross-Sectional Technologies 145 Active
US7723509B2 IRNA agents with biocleavable tethers Chemistry; Metallurgy 118 Active
US7582744B2 Chemically modified oligonucleotides Chemistry; Metallurgy 117 Expired
US7423142B2 Compositions and methods for inhibiting expression of anti-apoptotic genes Chemistry; Metallurgy 115 Expired
US7737265B2 RNAi modulation of HIF-1 and therapeutic uses thereof Chemistry; Metallurgy 111 Active
US7749978B2 Compositions and methods for inhibiting expression of Huntingtin gene Chemistry; Metallurgy 111 Active
US7829693B2 Compositions and methods for inhibiting expression of a target gene Chemistry; Metallurgy 108 Active
US9352048B2 Carbohydrate conjugates as delivery agents for oligonucleotides Emerging Cross-Sectional Technologies 99 Active
US9012498B2 Biodegradable lipids for the delivery of active agents Chemistry; Metallurgy 94 Active
US7786290B2 Double-stranded ribonucleic acid with increased effectiveness in an organism Chemistry; Metallurgy 92 Active
US9290760B2 Modified iRNA agents Chemistry; Metallurgy 90 Active
US9796974B2 Modified RNAi agents Chemistry; Metallurgy 85 Active
US7745608B2 Modified iRNA agents Chemistry; Metallurgy 79 Expired
US8110674B2 Therapeutic compositions Chemistry; Metallurgy 69 Expired
US8344125B2 Modified iRNA agents Chemistry; Metallurgy 51 Active
US8101584B2 Method and medicament for inhibiting the expression of a given gene Emerging Cross-Sectional Technologies 49 Expired
US8927513B2 5′ phosphate mimics Chemistry; Metallurgy 45 Active
US8546143B2 Compositions and methods for inhibiting expression of a target gene Chemistry; Metallurgy 44 Active

Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.