5′ phosphate mimics
US8927513B2 · kind B2 · utility
45Cited by
1References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 7, 2010 |
| Grant date | Jan 6, 2015 |
| Priority date | — |
| Expiry date | Jul 21, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/11
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides nucleosides and oligonucleotides comprising a 5′ phosphate mimics of formula (IVc) or (Vc). One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such dinucleotide of formula (Ia). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell; and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.