Inventor · Hopkinton, MA, US

Stephen E. Zale

53Patents
28h-index
45Co-inventors
88Inventor score

Filing activity: Jul 27, 1992 → Jun 8, 2018

Most-cited inventions

PatentTitleAreaCited byStatus
US5916597A Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent Human Necessities 241 Expired
US6495164B1 Preparation of injectable suspensions having improved injectability Human Necessities 163 Expired
US8613951B2 Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same Emerging Cross-Sectional Technologies 136 Active
US8734846B2 Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles Human Necessities 130 Active
US8709483B2 System for targeted delivery of therapeutic agents Human Necessities 117 Active
US8603501B2 Cancer cell targeting using nanoparticles Emerging Cross-Sectional Technologies 107 Active
US8617608B2 Drug loaded polymeric nanoparticles and methods of making and using same Emerging Cross-Sectional Technologies 105 Active
US8603500B2 Cancer cell targeting using nanoparticles Emerging Cross-Sectional Technologies 105 Active
US8603499B2 Cancer cell targeting using nanoparticles Emerging Cross-Sectional Technologies 105 Active
US8613954B2 Drug loaded polymeric nanoparticles and methods of making and using same Emerging Cross-Sectional Technologies 100 Active
US5674534A Composition for sustained release of non-aggregated erythropoietin Emerging Cross-Sectional Technologies 93 Expired
US5716644A Composition for sustained release of non-aggregated erythropoietin Human Necessities 92 Expired
US8246968B2 Cancer cell targeting using nanoparticles Emerging Cross-Sectional Technologies 89 Active
US8563041B2 Therapeutic particles suitable for parenteral administration and methods of making and using same Performing Operations; Transporting 83 Active
US8603534B2 Drug loaded polymeric nanoparticles and methods of making and using same Emerging Cross-Sectional Technologies 83 Active
US8603535B2 Stable formulations for lyophilizing therapeutic particles Emerging Cross-Sectional Technologies 80 Active
US8637083B2 Stable formulations for lyophilizing therapeutic particles Emerging Cross-Sectional Technologies 76 Active
US5683916A Membrane affinity apparatus and purification methods related thereto Emerging Cross-Sectional Technologies 74 Expired
US6667061B2 Preparation of injectable suspensions having improved injectability Human Necessities 67 Expired
US8211473B2 Stable formulations for lyophilizing therapeutic particles Emerging Cross-Sectional Technologies 62 Active
US8206747B2 Drug loaded polymeric nanoparticles and methods of making and using same Emerging Cross-Sectional Technologies 62 Active
US8273363B2 Cancer cell targeting using nanoparticles Emerging Cross-Sectional Technologies 57 Active
US8236330B2 Cancer cell targeting using nanoparticles Emerging Cross-Sectional Technologies 55 Active
US8318211B2 Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same Human Necessities 44 Active
US8318208B1 Drug loaded polymeric nanoparticles and methods of making and using same Emerging Cross-Sectional Technologies 43 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.