Inhibitors of the renal outer medullary potassim channel
US10000484B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Dec 16, 2014 |
| Grant date | Jun 19, 2018 |
| Priority date | — |
| Expiry date | Dec 16, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.