Salt forms of ceftolozane

US10000510B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Jian-Qiao Gu · Lexington, US
• Valdas Jurkauskas · Cambridge, US
• Carlos H. Lopez · Tlalnepantla, MX
• Kristos Adrian Moshos · Belmont, US
• Pradip M. Pathare · Lexington, US
• Sudhakar Devidasrao Garad · Malden, US
• You Seok Hwang · Windham, US

Key dates

• Filing date: Aug 17, 2015
• Grant date: Jun 19, 2018
• Expiry date: Aug 17, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C309/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.