Simplifying residue relationships in protein design
US10002231B2 · kind B2 · utility
1Cited by
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15Claims
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Key dates
| Filing date | Sep 29, 2011 |
| Grant date | Jun 19, 2018 |
| Priority date | — |
| Expiry date | Oct 20, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The invention provides a method of determining changes in a first set of residues r1 due to changes in a second set of residues r2 in a protein system comprising one or more proteins comprising r1 and r2. In exemplary embodiments, the method comprises optimizing a quality function Q by modifying one or more properties of r1 and r2 in a constrained environment in which all degrees of freedom of the system except those directly involved in the potential coupling between r1 and r2 are removed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.