Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof

US10010589B2 · kind B2 · utility

Assignees

• THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH · US
• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Weijun Shen · San Diego, US
• Pengyu Yang · San Diego, US
• Huafei Zou · San Diego, US
• Peter G. Schultz · Village of La Jolla, US

Key dates

• Filing date: Dec 17, 2014
• Grant date: Jul 3, 2018
• Expiry date: Jan 4, 2035

Classification

• Technology area (CPC —): General

Abstract

Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.