Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein

US10011572B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Pengcheng Patrick Shao · Fanwood, US
• Feng Ye · Scotch Plains, US
• Petr Vachal · Summit, US
• Jayanth Thiruvellore Thatal · Bengaluru, IN

Key dates

• Filing date: Jul 24, 2015
• Grant date: Jul 3, 2018
• Expiry date: Jul 24, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein D1, D2 and D3 are each N, CH, or substituted CH, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.