Cyclic peptide conjugates and methods of use

US10011635B2 · kind B2 · utility

Assignees

• H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. · US
• University of South Florida · US
• Modulation Therapeutics, Inc. · US
• THE SCRIPPS RESEARCH INSTITUTE · US

Inventors

• Lori Hazlehurst · Morgantown, US
• Christoph Rader · San Diego, US
• Xiuling Li · Tianshui, CN
• Mark McLaughlin · Tampa, US

Key dates

• Filing date: Sep 26, 2014
• Grant date: Jul 3, 2018
• Expiry date: Sep 26, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound adduct, a method for treating disorders such as proliferation disorders (e.g., malignancies), bone deficiency diseases, and autoimmune diseases, and a method for suppressing the growth of, or inducing apoptosis in, cells (e.g., malignant cells).