Regulation of specific spinal neurons regulating pain transmission via chimeric toxins
US10022450B2 · kind B2 · utility
2Cited by
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7Claims
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Key dates
| Filing date | Aug 19, 2016 |
| Grant date | Jul 17, 2018 |
| Priority date | — |
| Expiry date | Nov 5, 2036 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.