Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators

US10023589B2 · kind B2 · utility

Assignees

• Hoffmann-La Roche Inc. · US
• Roche Palo Alto LLC · US

Inventors

• Nidhi Arora · Cupertino, US
• Shaoqing Chen · Bound Brook, US
• Johannes Cornelius Hermann · Jersey City, US
• Andreas Kuglstatter · Soest, DE
• Sharada Labadie · Sunnyvale, US
• Clara Jeou Jen Lin · Palo Alto, US
• Matthew C. Lucas · Sunnyvale, US
• Amy Geraldine Moore · Mountain View, US
• Eva Papp · Palo Alto, US
• Francisco Xavier Talamas · Livingston, US
• Jutta Wanner · Palm Beach, US
• Yansheng Zhai · East Palo Alto, US

Key dates

• Filing date: Dec 18, 2015
• Grant date: Jul 17, 2018
• Expiry date: Dec 18, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.