Hoffmann-La Roche Inc.
4,943Patents
1,767Active
4,943Granted
53Portfolio score
Filing activity: Dec 5, 1968 → Mar 27, 2025 · 554 expiring within 5 years
Most-cited patents
| Patent | Title | Area | Cited by | Status |
|---|---|---|---|---|
| US5210015A | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase | Emerging Cross-Sectional Technologies | 871 | Expired |
| US5931814A | Dermally affixed injection device | Human Necessities | 860 | Expired |
| US4886499A | Portable injection appliance | Emerging Cross-Sectional Technologies | 781 | Expired |
| US5487972A | Nucleic acid detection by the 5'-3'exonuclease activity of polymerases acting on adjacently hybridized oligonucleotides | Emerging Cross-Sectional Technologies | 349 | Expired |
| US5512462A | Methods and reagents for the polymerase chain reaction amplification of long DNA sequences | Chemistry; Metallurgy | 337 | Expired |
| US5848990A | Device for introducing active substance into a patient | Human Necessities | 328 | Expired |
| US5322770A | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription | Chemistry; Metallurgy | 294 | Expired |
| US5333675A | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps | Emerging Cross-Sectional Technologies | 281 | Expired |
| US5418149A | Reduction of non-specific amplification glycosylase using DUTP and DNA uracil | Chemistry; Metallurgy | 280 | Expired |
| US5382657A | Peg-interferon conjugates | Human Necessities | 242 | Expired |
| US4326055A | Stilbene derivatives | Chemistry; Metallurgy | 228 | Expired |
| US5314809A | Methods for nucleic acid amplification | Chemistry; Metallurgy | 221 | Expired |
| US5235443A | Polarizer device | Physics | 220 | Expired |
| US5602661A | Optical component | Physics | 218 | Expired |
| US3961627A | Automatic regulation of respirators | Human Necessities | 216 | Expired |
| US5310652A | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription | Chemistry; Metallurgy | 215 | Expired |
| US5219727A | Quantitation of nucleic acids using the polymerase chain reaction | Chemistry; Metallurgy | 209 | Expired |
| US5455178A | Microoptical sensor and method | Emerging Cross-Sectional Technologies | 206 | Expired |
| US6039975A | Colon targeted delivery system | Human Necessities | 204 | Expired |
| US5319478A | Light control systems with a circular polarizer and a twisted nematic liquid crystal having a minimum path difference of .lambda./2 | Physics | 196 | Expired |
| US5618711A | Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase | Chemistry; Metallurgy | 188 | Expired |
| US5573906A | Detection of nucleic acids using a hairpin forming oligonucleotide primer and an energy transfer detection system | Chemistry; Metallurgy | 187 | Expired |
| US5747646A | Polyethylene-protein conjugates | Emerging Cross-Sectional Technologies | 181 | Expired |
| US5017487A | Vaccinia DNA | Emerging Cross-Sectional Technologies | 169 | Expired |
| US5411876A | Use of grease or wax in the polymerase chain reaction | Physics | 169 | Expired |
Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.