Gene signatures of inflammatory disorders that relate to the liver
US10036074B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 17, 2013 |
| Grant date | Jul 31, 2018 |
| Priority date | — |
| Expiry date | Oct 17, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention is related to the area of characterization of inflammation in relation with the gut microbiota, in metabolic and autoimmune disorders. In particular, it relates to the identification of gene signatures which can be used as a marker predictive of inflammation associated diseases, such as liver-related metabolic disorders, in particular to the evolution of benign steatosis towards its most severe forms (steatohepatitis and cirrhosis) or autoimmune disorders, in particular inflammatory bowel diseases (Crohn's and Ulcerative Colitis). These gene signatures can therefore be used as a means of diagnosis, prognosis, stratification for drug studies, for monitoring patient and for assigning an appropriate treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.