Patent assignee · FR · COMPANY

INSTITUT PASTEUR

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933Patents
359Active
933Granted
52Portfolio score

Filing activity: May 28, 1974 → Nov 8, 2024 · 126 expiring within 5 years

Most-cited patents

PatentTitleAreaCited byStatus
US4845205A 2,N.sup.6 -disubstituted and 2,N.sup.6 -trisubstituted adenosine-3'-phosphoramidites Chemistry; Metallurgy 483 Expired
US4109655A Multi-penetration vaccination apparatus Human Necessities 193 Expired
US4581333A Method of detecting and characterizing a nucleic acid or reactant for the application of this method Emerging Cross-Sectional Technologies 185 Expired
US8921332B2 Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site Chemistry; Metallurgy 153 Active
US5906817A Biocompatible implant for the expression and in vivo secretion of a therapeutic substance Chemistry; Metallurgy 152 Expired
US4708818A Human immunodeficiency viruses associated with Acquired Immune Deficiency Syndrome (AIDS), a diagnostic method for AIDS and pre-AIDS, and a kit therefor Emerging Cross-Sectional Technologies 145 Expired
US5798210A Derivatives utilizable in nucleic acid sequencing Chemistry; Metallurgy 135 Expired
US5871747A Antigen-carrying microparticles and their use in the indication of humoral or cellular responses Emerging Cross-Sectional Technologies 116 Expired
US6682907B1 Use of triplex structure DNA in transferring nucleotide sequences Chemistry; Metallurgy 89 Expired
US6833252B1 Nucleotide sequence encoding the enzyme I-SecI and the uses thereof Emerging Cross-Sectional Technologies 86 Expired
US6528313B1 Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made Chemistry; Metallurgy 84 Expired
US5747246A Process for determining the quantity of a DNA fragment of interest by a method of enzymatic amplification of DNA Chemistry; Metallurgy 80 Expired
US7416851B2 Method of diagnosis/prognosis of human chronic lymphocytic leukemia comprising the profiling of LPL/ADAM genes Chemistry; Metallurgy 76 Expired
US5635354A Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system Chemistry; Metallurgy 73 Expired
US6410724B1 Diagnostic means useful for predictive assessment of human hepatocellular carcinoma disease (HCC), as well as diagnostic methods using the same Chemistry; Metallurgy 73 Expired
US5376530A Steroid/thyroid hormone receptor-related gene, which is inappropriately expressed in human heptocellular carcinoma, and which is a retinoic acid receptor Emerging Cross-Sectional Technologies 73 Expired
US5840862A Process for aligning, adhering and stretching nucleic acid strands on a support surface by passage through a meniscus Emerging Cross-Sectional Technologies 72 Expired
US4839288A Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes Emerging Cross-Sectional Technologies 67 Expired
US6528314B1 Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made Chemistry; Metallurgy 66 Expired
US6559126B2 Peptides blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof Physics 63 Expired
US6638768B1 Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made Chemistry; Metallurgy 63 Expired
US4428941A Nucleotidic sequence coding the surface antigen of the hepatitis B virus, vector containing said nucleotidic sequence, process allowing the obtention thereof and antigen obtained thereby Emerging Cross-Sectional Technologies 62 Expired
US6011146A Altered major histocompatibility complex (MHC) determinant and methods of using the determinant Emerging Cross-Sectional Technologies 59 Expired
US4500512A Stabilizing agents for live viruses for preparing vaccines, and stabilized vaccines containing said stabilizing agents Emerging Cross-Sectional Technologies 58 Expired
US6686194B1 Method and device for selecting accelerated proliferation of living cells in suspension Emerging Cross-Sectional Technologies 56 Expired

Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.