Pyridyl-triazabicycles

US10047102B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Bjoern Bartels · Schopfheim, DE
• Cosimo Dolente · Allschwil, CH
• Wolfgang Guba · Memmingen, DE
• Wolfgang Haap · Bad Kötzting, DE
• Andreas Kuglstatter · Soest, DE
• Ulrike Obst Sander · Sursee, CH
• Jens-Uwe Peters · Weil am Rhein, DE
• Mark Rogers-Evans · Bottmingen, CH
• Thomas Woltering · Freiburg (Elbe), DE
• Christian Schnider · Basel, CH
• Roger Wermuth · Sissach, CH

Key dates

• Filing date: Jul 21, 2015
• Grant date: Aug 14, 2018
• Expiry date: Oct 24, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.