Tetrahydro-benzodiazepinones

US10053431B2 · kind B2 · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Shaoqing Chen · Bound Brook, US
• Andrew F. Donnell · Plainsboro, US
• Robert Francis Kester · Verona, US
• Kang Le · Green Brook, US
• Yan Lou · Pleasanton, US
• Christophe Michoud · New York, US
• Stacy Remiszewski · Hackettstown, US
• Kenneth Carey Rupert · Bedminster, US
• Martin Weisel · Mannheim, DE

Key dates

• Filing date: Nov 14, 2014
• Grant date: Aug 21, 2018
• Expiry date: Nov 14, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3, R4 and R5 are as described in this application, and methods of using said compounds in the treatment of cancer.