Process of producing cycloalkylcarboxamido-indole compounds

US10071979B2 · kind B2 · utility

Assignee

• Vertex Pharmaceuticals Incorporated · US

Inventors

• Gerald J. Tanoury · Marlborough, US
• Cristian Harrison · Beverly, US
• Benjamin Littler · Carlsbad, US
• Peter Jamison Rose · Littleton, US
• Robert Michael Hughes · San Diego, US
• Young Chun Jung · Lexington, US
• David Andrew Siesel · San Diego, US
• Elaine Chungmin Lee · Mundelein, US
• Daniel T. Belmont · Grafton, US
• William A. Nugent · Wilmington, US

Key dates

• Filing date: Apr 15, 2015
• Grant date: Sep 11, 2018
• Expiry date: Apr 15, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features processes for preparing compounds, such as (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1), useful for treating CFTR mediated diseases such as cystic fibrosis.