Tagged hepadnavirus e antigen and its use in screening antiviral substances
US10072047B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jun 19, 2015 |
| Grant date | Sep 11, 2018 |
| Priority date | — |
| Expiry date | Jun 19, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/02
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to methods and uses for screening anti-hepadnaviral substances, wherein the substances are screened for the capacity to inhibit covalently closed circular (ccc) DNA of a hepadnavirus, like hepatitis B virus. The methods and uses take advantage of cells comprising a nucleic sequence encoding a tagged hepadnavirus e antigen, like Hepatitis B virus e antigen (HBeAg). Furthermore, the present invention provides nucleic acid sequences encoding a tagged hepadnavirus e antigen and proteins encoded thereby. Also kits for use in the screening methods are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.