Phantom for diffusion MRI imaging

US10078124B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Ferenc Horkay · Rockville, US
• Carlo Pierpaoli · Rockville, US
• Peter J. Basser · Washington, US

Key dates

• Filing date: Mar 3, 2017
• Grant date: Sep 18, 2018
• Expiry date: Mar 16, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B2560/0228
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A phantom calibration body (12) for calibrating diffusion MRI device (16) that mimics a material such as a mammalian tissue is disclosed. The phantom calibration body (12) includes a homogeneous aqueous solution (30) that contains a mixture of low molecular-weight and high molecular-weight polymers housed in a container (14) that is placed in the diffusion MRI device (16) for obtaining one or more diffusion MRI images of the phantom calibration body (12). A measure of diffusivity is calculated for each of the one or more diffusion MRI images in order to calibrate the diffusion MRI device. Methods of using the phantom calibration body (12) to calibrate diffusion MRI device (16) are also disclosed.