Patent assignee · US · GOVERNMENT

The United States of America, as represented by the Secretary, Department of Health and Human Services

1,498Patents
1,450Active
1,498Granted
65Portfolio score

Filing activity: Aug 24, 1982 → Jun 11, 2024 · 215 expiring within 5 years

Most-cited patents

PatentTitleAreaCited byStatus
US8034334B2 Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy Human Necessities 216 Expired
US8211422B2 Chimeric receptor genes and cells transformed therewith Chemistry; Metallurgy 172 Expired
US8383099B2 Adoptive cell therapy with young T cells Chemistry; Metallurgy 159 Active
US8465743B2 Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer Physics 144 Active
US8796302B2 Methods related to the treatment of neurodegenerative and inflammatory conditions Human Necessities 130 Active
US9074185B2 Adoptive cell therapy with young T cells Chemistry; Metallurgy 114 Active
US8287857B2 Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy Human Necessities 76 Active
US9271833B2 Transcatheter coronary sinus mitral valve annuloplasty procedure and coronary artery and myocardial protection device Human Necessities 71 Active
US9765342B2 Chimeric antigen receptors targeting B-cell maturation antigen Chemistry; Metallurgy 70 Active
US7511032B2 Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto Human Necessities 70 Expired
US10078124B2 Phantom for diffusion MRI imaging Human Necessities 64 Active
US8283151B2 Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes Chemistry; Metallurgy 57 Active
US5672510A Retroviral vectors Chemistry; Metallurgy 51 Expired
US7928079B2 Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates Human Necessities 48 Active
US8846389B2 AAV4 vector and uses thereof Chemistry; Metallurgy 47 Active
US8454972B2 Method for inducing a multiclade immune response against HIV utilizing a multigene and multiclade immunogen Chemistry; Metallurgy 46 Active
US9238800B2 Avian adenoassociated virus and uses thereof Chemistry; Metallurgy 39 Active
US5698196A Antibodies specific for neutrophic chemotactic factor Emerging Cross-Sectional Technologies 39 Expired
US10166255B2 Intracellular genomic transplant and methods of therapy Chemistry; Metallurgy 39 Active
US9447452B2 Selective oxidation of 5-methylcytosine by TET-family proteins Physics 38 Active
US10051880B2 Hydroxybutyrate ester and medical use thereof Chemistry; Metallurgy 37 Active
US9163258B2 Method for the treatment of obesity Chemistry; Metallurgy 36 Active
US8388510B2 Transcranial magnetic stimulation system and methods Human Necessities 36 Active
US9439979B2 Epidermal growth factor receptor (EGFR) and methods of use in adenoviral-associated virus type 6 (AAV6) transduction Chemistry; Metallurgy 33 Active
US9044451B2 Use of delta tocopherol for the treatment of lysosomal storage disorders Human Necessities 32 Active

Source: USPTO / EPO open patent data. Counts and citation impact are objective bibliographic measures.