Patent · US Active

Thiazoles as modulators of RORγt

US10080744B2 · kind B2 · utility

0Cited by

1References

26Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Steven Goldberg · Encinitas, US
Christoph Steeneck · Dossenheim, DE
Christian Gege · Ehingen (Donau), DE
Olaf Kinzel · Heidelberg, DE
Gerald Kleymann · Bad Salzuflen, DE
Thomas Hoffmann · Santa Cruz, US
Anne Fourie · San Diego, US
Xiaohua Xue · San Diego, US

Key dates

Filing date	Nov 14, 2017
Grant date	Sep 25, 2018
Priority date	—
Expiry date	Nov 14, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention comprises compounds of Formula I wherein: R1, R2, R3, R4, R5, R7, R8, and {circle around (A)} are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.