Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties

US10087211B2 · kind B2 · utility

Assignees

• Research Triangle Institute · US
• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Scott P. Runyon · Morrisville, US
• Michael A. Rogawski · Sacramento, US
• Edgar Cook · Fairfax Station, US
• John A. Kepler · Raleigh, US
• Hernan A. Navarro · Chapel Hill, US
• Rafal Kaminski · Waterloo, BE
• Matthew Orr · Raleigh, US

Key dates

• Filing date: Nov 2, 2016
• Grant date: Oct 2, 2018
• Expiry date: Nov 2, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J31/003
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.