Purine inhibitors of human phosphatidylinositol 3-kinase delta

US10100064B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Meredeth A. McGowan · Boston, US
• Kin Chiu Fong · Shanghai, CN
• Neville J. Anthony · Hatfield, US
• Hua Zhou · Acton, US
• Jason Katz · Leominster, US
• Lihu Yang · Edison, US
• Chaomin Li · Boston, US
• Yuan Tian · Newton, US
• Changwei Mu · Beijing, CN
• Baijun Ye · Beijing, CN
• Feng Shi · Beijing, CN
• Xiaoli Zhao · Beijing, CN
• Jianmin Fu · Beijing, CN
• Yabin Li · Hangzhou City, CN

Key dates

• Filing date: Jun 9, 2015
• Grant date: Oct 16, 2018
• Expiry date: Jun 9, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The instant invention provides compounds of formula (I) which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.