Tablet formulation for CGRP active compounds

US10117836B2 · kind B2 · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Mary Ann Johnson · Norristown, US
• Leonardo R. Allain · Lansdale, US
• W. Mark Eickhoff · Downingtown, US
• Craig B. Ikeda · Harleysville, US
• Chad D. Brown · Quakertown, US
• Francis J. Flanagan, JR. · North Wales, US
• Rebecca Nofsinger · Lansdale, US
• Melanie Marota · Mount Laurel, US
• Lisa Lupton · South San Francisco, US
• Paresh B. Patel · Langhorne, US
• Hanmi Xi · Furlong, US
• Wei Xu · Saginaw, US

Key dates

• Filing date: Jan 30, 2015
• Grant date: Nov 6, 2018
• Expiry date: Jan 30, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/146
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein “Ra” is independently H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.