Photoactivatable lipid-based nanoparticles as vehicles for dual agent delivery

US10117942B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• Baylor College of Medicine · US

Inventors

• Anu Puri · Frederick, US
• Robert Blumenthal · Bethesda, US
• Amit Joshi · Westminster, US
• Darayash B. Tata · Silver Spring, US
• Mathias D. Viard · Frederick, US

Key dates

• Filing date: Jul 9, 2014
• Grant date: Nov 6, 2018
• Expiry date: Jul 9, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2005/0663
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine (DPPC), and (ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an agent within the cavity.