Modulators of the relaxin receptor 1

US10125112B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US
• The Florida International University Board of Trustees · US

Inventors

• Juan Jose Marugan · Gaithersburg, US
• Jingbo Xiao · Rockville, US
• Marc Ferrer-Alegre · Potomac, US
• Catherine Chen · Germantown, US
• Noel Terrence Southall · Bethesda, US
• Wei Zheng · Rockville, US
• Alexander Agoulnik · Miami, US
• Irina Agoulnik · Miami, US

Key dates

• Filing date: Aug 25, 2016
• Grant date: Nov 13, 2018
• Expiry date: Aug 25, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R1, and R2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.