Synthesis of cephalosporin compounds
US10125149B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 14, 2015 |
| Grant date | Nov 13, 2018 |
| Priority date | — |
| Expiry date | Aug 14, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising a palladium-catalyzed coupling reaction. Provided herein are methods for the synthesis of cephalosporin compounds of formula (I) employing a palladium-catalyzed alkylation reaction, as well as compositions related to the same. In an aspect, provided herein is a method for preparing a compound of formula (II), or a salt thereof, comprising the step of admixing, e.g., reacting, a compound of formula (III), or a salt thereof, with a nucleophile (Nuc) in the presence of reagents comprising: (a) a palladium source; and (b) a palladium-binding ligand, to form a compound of formula (II), or a salt thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.