Compositions and methods for altering second messenger signaling

US10131686B2 · kind B2 · utility

Assignees

• Memorial Sloan Kettering Cancer Center · US
• The Rockefeller University · US
• Rutgers, the State University of New Jersey · US
• University of Bonn · DE

Inventors

• Dinshaw J. Patel · New York, US
• Thomas Tuschl · Oettingen, DE
• Manuel Ascano, Jr. · New York, US
• Yang-Chang Wu
• Yizhou Liu · New York, US
• Winfried Barchet · Bonn, DE
• Gunther Hartmann · Munich, DE
• Thomas Zillinger · Bonn, DE
• Roger A. Jones · New Brunswick, US
• Barbara L. Gaffney · Fryeburg, US
• Pu-Xian Gao · Coventry, US

Key dates

• Filing date: Dec 8, 2017
• Grant date: Nov 20, 2018
• Expiry date: Dec 8, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions, methods, kits, and assays related to the use and/or exploitation of isomers of cGAMP as well as the structure of the enzyme cGAS.