Lipidated incretin receptor ligand human immunoglobulin Fc-region fusion polypeptides

US10137170B2 · kind B2 · utility

Assignees

• INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION · US
• Hoffmann-La Roche Inc. · US

Inventors

• Sara Belli · Oberrohrdorf, CH
• Konrad Bleicher · Glückstadt, DE
• Richard D. DiMarchi · Carmel, US
• Eike Hoffmann · Viernheim, DE
• Eric A. Kitas · Aesch, CH
• Anish Ashok Konkar · Guttenberg, US

Key dates

• Filing date: Dec 19, 2014
• Grant date: Nov 27, 2018
• Expiry date: Dec 19, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Herein is reported a fusion polypeptide comprising i) one, two, three or four incretin receptor ligand polypeptides, and ii) one human immunoglobulin Fc-region, wherein at least one of the incretin receptor ligand polypeptides comprises an amino acid that is covalently conjugated to a lipid, and wherein each of the one, two, three or four incretin receptor ligand polypeptides is covalently conjugated by a peptide bond to a terminus of the human immunoglobulin Fc-region, whereby to each terminus of the human immunoglobulin Fc-region only a single incretin receptor ligand polypeptide is conjugated.