Trifluoromethyl alcohols as modulators of RORγt

US10150762B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Steven Goldberg · Encinitas, US
• Hariharan Venkatesan · San Diego, US
• Olaf Kinzel · Heidelberg, DE
• Christian Gege · Ehingen (Donau), DE
• Christoph Steeneck · Dossenheim, DE
• Gerald Kleymann · Bad Salzuflen, DE
• Thomas Hoffmann · Santa Cruz, US

Key dates

• Filing date: Jul 31, 2017
• Grant date: Dec 11, 2018
• Expiry date: Jul 31, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention comprises methods of making 5-(2,3-dichloro-4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2-hydroxy-2-methylpropyl)-4-(R1-1-carbonyl)thiazole-2-carboxamide, wherein R1 is defined in the specification.