Therapeutic compounds and uses thereof

US10150767B2 · kind B2 · utility

Assignees

• Genentech, Inc. · US
• Constellation Pharmaceuticals, Inc. · US

Inventors

• Brian K. Albrecht · Cambridge, US
• Steven Bellon · Wellesley, US
• Daniel J. Burdick · Burlingame, US
• Alexandre Cote · Cambridge, US
• Terry Crawford · San Mateo, US
• Les A. Dakin · Natick, US
• Vickie Hsiao-Wei Tsui · South San Francisco, US
• Michael Charles Hewitt · Somerville, US
• Yves LeBlanc · Toronto, CA
• Steven R. Magnuson · South San Francisco, US
• Christopher G. Nasveschuk · Stoneham, US
• Anthony F. Romero · South San Francisco, US
• Yong Tang · Cambridge, US
• Alexander M. Taylor · Cambridge, US
• Shumei Wang · Foster City, US

Key dates

• Filing date: May 10, 2017
• Grant date: Dec 11, 2018
• Expiry date: May 10, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): and to salts thereof, wherein R1, R2, and Q have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of bromodomains. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various bromodomain-mediated disorders.