Chromatography process for purification of insulin and insulin analogs
US10155799B2 · kind B2 · utility
0Cited by
10References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 16, 2015 |
| Grant date | Dec 18, 2018 |
| Priority date | — |
| Expiry date | Jul 16, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/20
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A process is described for purifying insulin and insulin analogs that comprises use of two or more orthogonal chromatographic purification steps in tandem following enzymatic digestion of the propeptide-insulin precursor to remove specific product impurities, improve process consistency, and increase process redundancy in the purification of the insulin or insulin analog, e.g., insulin lispro.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.