Multi-focal structured illumination microscopy systems and methods

US10156711B2 · kind B2 · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Hari Shroff · Rockville, US
• Andrew York · Bethesda, US

Key dates

• Filing date: Mar 19, 2018
• Grant date: Dec 18, 2018
• Expiry date: Mar 19, 2038

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2201/105
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Various embodiments for a multi-focal selective illumination microscopy (SIM) system for generating multi-focal patterns of a sample are disclosed. The multi-focal SIM system performs a focusing, scaling and summing operation on each generated multi-focal pattern in a sequence of multi-focal patterns that completely scan the sample to produce a high resolution composite image.