Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof

US10172814B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Nico Bräuer · Falkensee, DE
• Jens Nagel · Daxweiler, DE
• Horst IRLBACHER · Berlin, DE
• Andrea Rotgeri · Berlin, DE
• Wolfgang Schwede · Berlin, DE
• Henrik DAHLLÖF · Uppsala, SE
• Marcus Koppitz · Berlin, DE
• Michaele PETERS · Berlin, DE
• Anne-Marie Godinho-Coelho · Hamburg, DE

Key dates

• Filing date: Dec 16, 2015
• Grant date: Jan 8, 2019
• Expiry date: Dec 16, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted Pyridyl-cycloalkyl-carboxylic acids of general formula (I), to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular in mammals, such as diseases associated with pains, or for the treatment or prophylaxis of pain syndromes (acute and chronic), inflammatory-induced pain, pelvic pain, cancer-associated pain, endometriosis-associated pain as well as endometriosis and adenomyosis as such, cancer as such, and proliferative diseases as such like endometriosis.