Isoform of anaplastic lymphoma kinase and its uses
US10190104B2 · kind B2 · utility
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Key dates
| Filing date | Oct 7, 2016 |
| Grant date | Jan 29, 2019 |
| Priority date | — |
| Expiry date | Oct 7, 2036 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.